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Home Therapy Central nervous system

encefalitis/meningitis - Herpes simplex

Advices

≥ 18 years
Priority Medication Remarks
Medication:

aciclovir iv 10mg/kg 3dd minimum 14 days
Remarks:

Voor behandelduur: zie Opmerkingen.

General comments

Een behandelduur van 10 dagen aciclovir iv voor Herpes simplex encefalitis is uitgezocht in randomized controlled trials. Gezien er klinisch relapsen zijn beschreven na een behandelduur van 10 dagen is de expert based opinion om 14 - 21 dagen te behandelen.

Voor advies over behandeling en resistentiebepaling kunt u bellen met de dienstdoende viroloog 67014 of via de centrale (buiten kantooruren).

Sources

  1. Pubmed.gov publication # 18582201

    Tunkel et al., The management of encephalitis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis. 2008 Aug 1;47(3):303-27.

  2. Pubmed.gov publication # 22120594

    Kneen et al., National Encephalitis Guidelines Development and Stakeholder Groups. Management of suspected viral encephalitis in children - Association of British Neurologists and British Paediatric Allergy, Immunology and Infection Group national guidelines. J Infect. 2012 May;64(5):449-77.

  3. Pubmed.gov publication # 3001520

    Whitley et al., Vidarabine versus acyclovir therapy in herpes simplex encephalitis. N Engl J Med. 1986 Jan 16;314(3):144-9.

  4. Pubmed.gov publication # 6148470

    Sköldenberg et al., Acyclovir versus vidarabine in herpes simplex encephalitis. Randomised multicentre study in consecutive Swedish patients. Lancet. 1984 Sep 29;2(8405):707-11.

  5. https://kennisbank.knmp.nl/
Antimicrobial resources

The following antimicrobial agents have been used in these recommendations:

External antimicrobial resources
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Metadata

Swab vid: G-212072.4
Updated: 12/12/2022 - 10:52
Status: Published